Invention Grant
US07919242B2 Light emission modifiers and their uses in nucleic acid detection, amplification and analysis
有权
光发射调节剂及其在核酸检测，扩增和分析中的应用
- Patent Title: Light emission modifiers and their uses in nucleic acid detection, amplification and analysis
- Patent Title (中): 光发射调节剂及其在核酸检测，扩增和分析中的应用
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Application No.: US11474062Application Date: 2006-06-23
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Publication No.: US07919242B2Publication Date: 2011-04-05
- Inventor: Amar P. Gupta , Stephen Gordon Will
- Applicant: Amar P. Gupta , Stephen Gordon Will
- Applicant Address: US CA Pleasanton
- Assignee: Roche Molecular Systems, Inc.
- Current Assignee: Roche Molecular Systems, Inc.
- Current Assignee Address: US CA Pleasanton
- Agent Olga Kay; Vivien Banholzer; David J. Chang
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07H21/02 ; C07H21/04 ; C07D513/00
Abstract:
The present invention relates to methods and reagents for modifying the emission of light from labeled nucleic acids for the purpose of real time detection, analysis, and quantitation of nucleic acid sequences, e.g., using singly labeled probes. These methods and reagents exploit advantageous properties of thiazine dyes and diazine dyes. Furthermore, the use of these light emission modifiers in background reduction, nucleic acid duplex stabilization and other uses is also described. Related kits, reaction mixtures and integrated systems are described.
Public/Granted literature
- US20070020664A1 Light emission modifiers and their uses in nucleic acid detection, amplification and analysis Public/Granted day:2007-01-25
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