Invention Grant
- Patent Title: Constitutive gene expression in conjunction with ionizing radiation
- Patent Title (中): 与电离辐射结合的组成型基因表达
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Application No.: US12019428Application Date: 2008-01-24
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Publication No.: US07919310B2Publication Date: 2011-04-05
- Inventor: Ralph R. Weichselbaum , Dennis E. Hallahan , Donald W. Kufe , Vikas P. Sukhatme
- Applicant: Ralph R. Weichselbaum , Dennis E. Hallahan , Donald W. Kufe , Vikas P. Sukhatme
- Applicant Address: US IL Chicago US MA Boston
- Assignee: The University of Chicago,Dana-Farber Cancer Institute
- Current Assignee: The University of Chicago,Dana-Farber Cancer Institute
- Current Assignee Address: US IL Chicago US MA Boston
- Agency: Andrus, Sceales, Starke & Sawall, LLP
- Main IPC: C12N15/74
- IPC: C12N15/74
Abstract:
The present disclosure demonstrates the successful use of constitutive promoters operatively linked to genes encoding radiosensitizing or radioprotecting factors, administered to cells, tissues, or patients in conjunction with radiation exposure. Also disclosed are pharmacological preparations to be used to increase the levels of radiosensitizing compounds such as TNF-α, or radioprotective compounds such as MnSOD, in specified tissues or tumors of a subject.
Public/Granted literature
- US20080118471A1 CONSTITUTIVE GENE EXPRESSION IN CONJUNCTION WITH IONIZING RADIATION Public/Granted day:2008-05-22
Information query
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