Invention Grant
US07919317B2 Methods of differentiating and protecting cells by modulating the P38/MEF2 pathway
有权
通过调节P38 / MEF2途径分化和保护细胞的方法
- Patent Title: Methods of differentiating and protecting cells by modulating the P38/MEF2 pathway
- Patent Title (中): 通过调节P38 / MEF2途径分化和保护细胞的方法
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Application No.: US09876187Application Date: 2001-06-05
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Publication No.: US07919317B2Publication Date: 2011-04-05
- Inventor: Stuart A. Lipton , Shu-ichi Okamoto
- Applicant: Stuart A. Lipton , Shu-ichi Okamoto
- Applicant Address: US CA La Jolla
- Assignee: Sanford-Burnham Medical Research Institute
- Current Assignee: Sanford-Burnham Medical Research Institute
- Current Assignee Address: US CA La Jolla
- Agency: Jones Day
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/02 ; C12N5/071 ; C12N15/00
Abstract:
The present invention provides a method of differentiating progenitor cells to produce a population containing protected neuronal cells. A method of the invention includes the steps of contacting the progenitor cells with a differentiating agent; and introducing into the progenitor cells a nucleic acid molecule encoding a MEF2 polypeptide or an active fragment thereof, thereby differentiating the progenitor cells to produce a population containing protected neuronal cells. In one embodiment, the MEF2 polypeptide is human MEF2C or an active fragment thereof.
Public/Granted literature
- US20020090603A1 Methods of differentiating and protecting cells by modulating the P38/MEF2 pathway Public/Granted day:2002-07-11
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