Invention Grant
- Patent Title: Targeted deletions using retroelement-mediated placement of recombination sites
- Patent Title (中): 使用逆转录介导置换重组位点的靶向缺失
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Application No.: US11391972Application Date: 2006-03-29
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Publication No.: US07919322B2Publication Date: 2011-04-05
- Inventor: Melissa Spears , Greg Davis , Kevin Kayser
- Applicant: Melissa Spears , Greg Davis , Kevin Kayser
- Applicant Address: US MO St. Louis
- Assignee: Sigma-Aldrich Co.
- Current Assignee: Sigma-Aldrich Co.
- Current Assignee Address: US MO St. Louis
- Agency: Polsinelli Shughart PC
- Main IPC: C12N15/74
- IPC: C12N15/74 ; C12N15/63 ; C12N15/64 ; C12N15/65 ; C12N15/00 ; C12P21/00
Abstract:
The present invention provides methods, nucleic acid constructs, and kits for selectively deleting a region of a nucleic acid sequence. Specifically, it utilizes retargeting retroelements to place site-specific recombination sites at targeted locations in the nucleic acid sequence. The region between the recombination sites is then deleted using a site-specific recombination system.
Public/Granted literature
- US20070231865A1 Targeted deletions using retroelement-mediated placement of recombination sites Public/Granted day:2007-10-04
Information query
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