Invention Grant
- Patent Title: Marked peptides having affinity for a phospholipid and uses
- Patent Title (中): 标记肽对磷脂具有亲和力并使用
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Application No.: US10518382Application Date: 2003-06-30
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Publication No.: US07919455B2Publication Date: 2011-04-05
- Inventor: Alain Sanson , Francoise Ochsenbein , Frederic Dolle
- Applicant: Alain Sanson , Francoise Ochsenbein , Frederic Dolle
- Applicant Address: FR Paris FR Paris
- Assignee: Commissariat a l'Energie Atomique,Universite Pierre et Marie Curie (Paris VI)
- Current Assignee: Commissariat a l'Energie Atomique,Universite Pierre et Marie Curie (Paris VI)
- Current Assignee Address: FR Paris FR Paris
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: FR0208204 20020701
- International Application: PCT/FR03/02027 WO 20030630
- International Announcement: WO2004/003016 WO 20040108
- Main IPC: A61K38/16
- IPC: A61K38/16

Abstract:
The present invention relates to a peptide labelled with fluorine-18 for the specific recognition of lipid vectors. The peptide of the invention comprises the following peptide sequence (PI): (I) J1-J2-J3-J4-J5-J6-Z7-U8-J9-J10-U11-Arg-J13-J14- U15-Lys-Gly-X18-Gly-Thr-J21-Glu-J23-J24-U25-J26- J27-J28-U29-J30-J31-Arg-J33-J34-J35-J36-B37-J38- J39-U40-J41-J42-J43-U44-J45-J46-J47-J48-J49-Arg- J51-U52-J53-J54-Asp-U56-Lys-Ser-Z59-Leu-J61-J62- J63-J64-Z65-J66-J67-U68-J69-J70-J71-U72-J73-J74-J75 in which the amino acids J are chosen independently of each other from natural amino acids, or derivatives thereof, in such a manner that at least 50% of them are polar residues chosen from Arg, Asn, Asp, Cys, Gln, Glu, Gly, His, Lys, Orn, Pro, Ser, Thr and Tyr, the amino acids U are chosen from Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr and Val, the amino acid X18 is chosen independently of the other amino acids of the sequence from Ala, Asn, Cys, Gln, Gly, His, Ile, Leu, Met, Phe, Ser, Thr, Trp, Tyr and Val, the amino acid B37 is chosen independently of the other amino acids of the sequence from Arg, Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr and Val, the amino acid Z7 is chosen independently of the other amino acids from Asp and Glu, the amino acids Z59 and Z65 are chosen independently from Glu, Asp, Lys and Arg, the superscripts of the residues J, Z, U, X and B representing the positions of these amino acids in the said sequence.
Public/Granted literature
- US20060233706A1 Marked peptides having affinity for a phospholipid and uses Public/Granted day:2006-10-19
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