Invention Grant
US07919464B2 Use of a peptide that interacts with αvβ3 integrin of endothelial cell
有权
使用与αv＆bgr 3内皮细胞整合素相互作用的肽
- Patent Title: Use of a peptide that interacts with αvβ3 integrin of endothelial cell
- Patent Title (中): 使用与αv＆bgr 3内皮细胞整合素相互作用的肽
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Application No.: US10552291Application Date: 2004-04-02
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Publication No.: US07919464B2Publication Date: 2011-04-05
- Inventor: Ju-Ock Nam , Jung-Eun Kim , Ha-Won Jeong , Sung-Jin Lee , Byung-Heon Lee , Je-Yong Choi , Rang-Woon Park , Jae-Yong Park , In-San Kim
- Applicant: Ju-Ock Nam , Jung-Eun Kim , Ha-Won Jeong , Sung-Jin Lee , Byung-Heon Lee , Je-Yong Choi , Rang-Woon Park , Jae-Yong Park , In-San Kim
- Applicant Address: KR Daegu
- Assignee: Kyungpook National University Industry-Academic Cooperation Foundation
- Current Assignee: Kyungpook National University Industry-Academic Cooperation Foundation
- Current Assignee Address: KR Daegu
- Agency: Edwards Angell Palmer & Dodge LLP
- Agent Kongsik Kim, Esq.
- Priority: KR10-2003-0021065 20030403
- International Application: PCT/KR2004/000774 WO 20040402
- International Announcement: WO2004/087193 WO 20041014
- Main IPC: A61K38/10
- IPC: A61K38/10 ; A61K38/16
Abstract:
The present invention relates to the use of a peptide that interacts with the αvβ3 integrin of endothelial cells. More particularly, the invention relates to a method for inhibiting endothelial cell adhesion, endothelial cell migration and/or angiogenesis, using a peptide consisting of at least 18 amino acids, comprising tyrosine-histidine (TY) or asparagines-histidine (NH), and at least three hydrophobic amino acids with bulky side chains; or equivalents thereof. Furthermore, the invention provides a method for treating or preventing angiogenesis-related diseases, using the peptide.
Public/Granted literature
- US20070004622A1 Imidazole derivative, process for producing the same, and use Public/Granted day:2007-01-04
Information query
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