Invention Grant
- Patent Title: Enhanced antisense oligonucleotides
- Patent Title (中): 增强的反义寡核苷酸
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Application No.: US11231243Application Date: 2005-09-19
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Publication No.: US07919472B2Publication Date: 2011-04-05
- Inventor: Brett P. Monia , Andrew M. Siwkowski , Sanjay Bhanot
- Applicant: Brett P. Monia , Andrew M. Siwkowski , Sanjay Bhanot
- Applicant Address: US CA Carlsbad
- Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Jones Day
- Main IPC: A01N43/04
- IPC: A01N43/04 ; C12Q1/68 ; C12N15/63 ; C07H21/02 ; C07H21/04
Abstract:
Described herein are gap-widened antisense oligonucleotides having improved therapeutic index as compared to 5-10-5 MOE gapmer antisense oligonucleotides of the same sequence. Also described are methods of reducing a target RNA in an animal using the gap-widened antisense oligonucleotides of the present invention. Further, are methods for selecting a gap-widened antisense oligonucleotides.
Public/Granted literature
- US20060063730A1 Enhanced antisense oligonucleotides Public/Granted day:2006-03-23
Information query
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