Invention Grant
US07919496B2 Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes
失效
用于治疗由硬脂酰辅酶A去饱和酶介导的疾病的杂环衍生物
- Patent Title: Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes
- Patent Title (中): 用于治疗由硬脂酰辅酶A去饱和酶介导的疾病的杂环衍生物
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Application No.: US11575636Application Date: 2005-09-20
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Publication No.: US07919496B2Publication Date: 2011-04-05
- Inventor: Rajender Kamboj , Zaihui Zhang , Jianmin Fu , Vishnumurthy Kodumuru , Shifeng Liu , Shaoyi Sun , Nagasree Chakka
- Applicant: Rajender Kamboj , Zaihui Zhang , Jianmin Fu , Vishnumurthy Kodumuru , Shifeng Liu , Shaoyi Sun , Nagasree Chakka
- Applicant Address: CA Burnaby
- Assignee: Xenon Pharmaceuticals Inc.
- Current Assignee: Xenon Pharmaceuticals Inc.
- Current Assignee Address: CA Burnaby
- Agency: Seed IP Law Group PLLC
- Agent Thong N. Trinh
- International Application: PCT/US2005/033744 WO 20050920
- International Announcement: WO2006/034315 WO 20060330
- Main IPC: A61K31/381
- IPC: A61K31/381 ; C07D271/113 ; C07D285/135 ; A61K31/50 ; A61K31/415 ; C07D237/20 ; C07D237/24 ; C07D231/38 ; C07D277/42
Abstract:
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Public/Granted literature
- US20080108629A1 Heterocyclic Derivatives for the Treatment of Diseases Mediated by Stearoyl-Coa Desaturase Enzymes Public/Granted day:2008-05-08
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