Invention Grant
- Patent Title: Bis-carbazole DNA intercalating agents for antitumor therapy
- Patent Title (中): 用于抗肿瘤治疗的双咔唑DNA插层剂
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Application No.: US12499149Application Date: 2009-07-08
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Publication No.: US07919500B2Publication Date: 2011-04-05
- Inventor: Gordon W. Gribble , Dmitry A. Androsov
- Applicant: Gordon W. Gribble , Dmitry A. Androsov
- Applicant Address: US NH Hanover
- Assignee: Trustees of Dartmouth College
- Current Assignee: Trustees of Dartmouth College
- Current Assignee Address: US NH Hanover
- Agency: Licata & Tyrrell P.C.
- Main IPC: A61K31/4353
- IPC: A61K31/4353 ; A61K31/437 ; A61K31/403 ; C07D209/82 ; C07D209/88 ; C07D471/02 ; C07D471/04
Abstract:
The present invention is a DNA intercalating agent represented by the structure Y—Z—Y, wherein Y is an anti-tumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, containing at least two aromatic rings, or at least two alicyclic rings, wherein the rings are linked in a 1,4 or 1,3 manner. Methods of inhibiting cancer cells and treating subjects having cancer with these agents are also provided.
Public/Granted literature
- US20100010033A1 Bis-carbazole DNA intercalating agents for antitumor therapy Public/Granted day:2010-01-14
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