Invention Grant
- Patent Title: Thiadiazole modulators of PKB
- Patent Title (中): PKB的噻二唑调节剂
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Application No.: US12218523Application Date: 2008-07-15
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Publication No.: US07919504B2Publication Date: 2011-04-05
- Inventor: Qingping Zeng , Chester Chenguang Yuan , Guomin Yao , Xianghong Wang , Seifu Tadesse , Andreas Reichelt , Qingyian Liu , Matthew R. Lee , Xin Huang , Fang-Tsao Hong , Nianhe Han , Christopher H. Fotsch , Celia Dominguez , Matthew P. Bourbeau , John G. Allen
- Applicant: Qingping Zeng , Chester Chenguang Yuan , Guomin Yao , Xianghong Wang , Seifu Tadesse , Andreas Reichelt , Qingyian Liu , Matthew R. Lee , Xin Huang , Fang-Tsao Hong , Nianhe Han , Christopher H. Fotsch , Celia Dominguez , Matthew P. Bourbeau , John G. Allen
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Bernard P. Friedrichsen
- Main IPC: A61K31/47
- IPC: A61K31/47 ; C07D401/04
Abstract:
The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
Public/Granted literature
- US20090298836A1 Thiadiazole modulators of PKB Public/Granted day:2009-12-03
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