Invention Grant
US07919518B2 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40
有权
1-苄基-3-羟甲基吲唑衍生物及其在治疗基于MCP-1，CX3CR1和p40表达的疾病中的应用
- Patent Title: 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40
- Patent Title (中): 1-苄基-3-羟甲基吲唑衍生物及其在治疗基于MCP-1，CX3CR1和p40表达的疾病中的应用
-
Application No.: US12864767Application Date: 2009-03-05
-
Publication No.: US07919518B2Publication Date: 2011-04-05
- Inventor: Angelo Guglielmotti , Guido Furlotti , Giorgina Mangano , Nicola Cazzolla , Barbara Garofalo
- Applicant: Angelo Guglielmotti , Guido Furlotti , Giorgina Mangano , Nicola Cazzolla , Barbara Garofalo
- Applicant Address: IT Rome
- Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
- Current Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
- Current Assignee Address: IT Rome
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: EP08425139 20080307
- International Application: PCT/EP2009/052590 WO 20090305
- International Announcement: WO2009/109618 WO 20090911
- Main IPC: A61K31/416
- IPC: A61K31/416 ; C07D231/56
Abstract:
The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40, and to their use in a method for treating or preventing diseases based on the expression of MCP-1, CX3CR1 and p40.
Public/Granted literature
Information query
IPC分类:
