Invention Grant
- Patent Title: Inhibitors of aspartyl protease
- Patent Title (中): 天冬氨酰蛋白酶抑制剂
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Application No.: US12217517Application Date: 2008-07-02
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Publication No.: US07919523B2Publication Date: 2011-04-05
- Inventor: Michael R. Hale , Christopher T. Baker , Timothy A. Stammers , Ronald George Sherrill , Andrew Spaltenstein , Eric Steven Furfine , Francois Maltais , Clarence Webster Andrews, III , John Franklin Miller , Vicente Samano
- Applicant: Michael R. Hale , Christopher T. Baker , Timothy A. Stammers , Ronald George Sherrill , Andrew Spaltenstein , Eric Steven Furfine , Francois Maltais , Clarence Webster Andrews, III , John Franklin Miller , Vicente Samano
- Applicant Address: US MA Cambridge
- Assignee: Vertex Pharmaceuticals, Inc.
- Current Assignee: Vertex Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Ropes & Gray LLP
- Agent James F. Haley, Jr.; Karen Mangasarian
- Main IPC: A61K31/357
- IPC: A61K31/357 ; C07D319/06
Abstract:
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
Public/Granted literature
- US20090042973A1 Inhibitors of aspartyl protease Public/Granted day:2009-02-12
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