Invention Grant
- Patent Title: δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amides
- Patent Title (中): δ-氨基-γ-羟基-ω-芳基 - 链烷酸酰胺
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Application No.: US12483599Application Date: 2009-06-12
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Publication No.: US07919529B2Publication Date: 2011-04-05
- Inventor: Daniel Kaspar Baeschlin , Juergen Klaus Maibaum , Holger Sellner
- Applicant: Daniel Kaspar Baeschlin , Juergen Klaus Maibaum , Holger Sellner
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Sophie Binet Cross
- Main IPC: A61K31/65
- IPC: A61K31/65

Abstract:
Disclosed are δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and methods of administering them for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.
Public/Granted literature
- US20090253703A1 ORGANIC COMPOUNDS Public/Granted day:2009-10-08
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