Invention Grant
- Patent Title: Human antibodies to human delta like ligand 4
- Patent Title (中): 人类抗体人类抗体如配体4
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Application No.: US12002245Application Date: 2007-12-14
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Publication No.: US07919593B2Publication Date: 2011-04-05
- Inventor: Nicholas J. Papadopoulos , Joel H. Martin , Eric Smith , Irene Noguera-Troise , Gavin Thurston
- Applicant: Nicholas J. Papadopoulos , Joel H. Martin , Eric Smith , Irene Noguera-Troise , Gavin Thurston
- Applicant Address: US NY Tarrytown
- Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee Address: US NY Tarrytown
- Agent Valeta Gregg, Esq.; Izumi Yokoyama, Esq.
- Main IPC: C07K16/00
- IPC: C07K16/00

Abstract:
An isolated human antibody or a fragment of a human antibody which specifically binds to human delta-like ligand 4 (hDll4) and blocks hDll4 binding to a Notch receptor. The human anti-hDll4 antibody or antibody fragment binds hDll4 with an affinity of ≦500 pM, as measured by surface plasmon resonance.
Public/Granted literature
- US20080181899A1 Human antibodies to human delta like ligand 4 Public/Granted day:2008-07-31
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