Invention Grant
US07919612B2 2′-substituted oligomeric compounds and compositions for use in gene modulations
有权
2'-取代的寡聚化合物和用于基因调节的组合物
- Patent Title: 2′-substituted oligomeric compounds and compositions for use in gene modulations
- Patent Title (中): 2'-取代的寡聚化合物和用于基因调节的组合物
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Application No.: US10701316Application Date: 2003-11-04
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Publication No.: US07919612B2Publication Date: 2011-04-05
- Inventor: Brenda F. Baker , Anne B. Eldrup , Muthiah Manoharan , Balkrishen Bhat , Richard Griffey , Eric E. Swayze , Stanley T. Crooke , Thazha P. Prakash
- Applicant: Brenda F. Baker , Anne B. Eldrup , Muthiah Manoharan , Balkrishen Bhat , Richard Griffey , Eric E. Swayze , Stanley T. Crooke , Thazha P. Prakash
- Applicant Address: US CA Carlsbad
- Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Isis Patent Department
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C07H21/02 ; A61K48/00
Abstract:
Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modified sugar and/or backbone modification. In some embodiments the modification is a 2′ substituent group on a sugar moiety that is not H or OH. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide of the oligomer has a modified sugar and/or backbone modification.
Public/Granted literature
- US20040171033A1 2'-substituted oligomeric compounds and compositions for use in gene modulations Public/Granted day:2004-09-02
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