Invention Grant
- Patent Title: RNAi modulation of SCAP and therapeutic uses thereof
- Patent Title (中): SCAP的RNAi调节及其治疗用途
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Application No.: US12749159Application Date: 2010-03-29
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Publication No.: US07919613B2Publication Date: 2011-04-05
- Inventor: Juergen Soutschek , Pamela Tan , Jay D. Horton , Michael S. Brown , Joseph L. Goldstein , Young-Ah Moon
- Applicant: Juergen Soutschek , Pamela Tan , Jay D. Horton , Michael S. Brown , Joseph L. Goldstein , Young-Ah Moon
- Applicant Address: US MA Cambridge US TX Austin
- Assignee: Alnylam Pharmaceuticals, Inc.,Board of Regents, the Unversity of Texas System
- Current Assignee: Alnylam Pharmaceuticals, Inc.,Board of Regents, the Unversity of Texas System
- Current Assignee Address: US MA Cambridge US TX Austin
- Agency: Fulbright & Jaworski L.L.P.
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C07H21/02 ; A61K48/00 ; C12N15/63 ; C12N15/85
Abstract:
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a SCAP gene (Human SCAP gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a SCAP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Human SCAP expression and the expression of a SCAP gene using the pharmaceutical composition; and methods for inhibiting the expression of a SCAP gene in a cell.
Public/Granted literature
- US20100184829A1 RNAI MODULATION OF SCAP AND THERAPEUTIC USES THEREOF Public/Granted day:2010-07-22
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