Invention Grant
- Patent Title: VR1 vanilloid receptor antagonists with a iononic substructure
- Patent Title (中): 具有离子亚结构的VR1香草素受体拮抗剂
-
Application No.: US12307919Application Date: 2007-07-02
-
Publication No.: US07919624B2Publication Date: 2011-04-05
- Inventor: Pier Giovanni Baraldi , Pier Andrea Borea , Pierangelo Geppetti , Maria Giovanna Pavani , Francesca Fruttarolo , Marcello Trevisani
- Applicant: Pier Giovanni Baraldi , Pier Andrea Borea , Pierangelo Geppetti , Maria Giovanna Pavani , Francesca Fruttarolo , Marcello Trevisani
- Applicant Address: IT Ferrara
- Assignee: Pharmeste S.R.L.
- Current Assignee: Pharmeste S.R.L.
- Current Assignee Address: IT Ferrara
- Agency: Steinfl & Bruno LLP
- Priority: EP06014299 20060710
- International Application: PCT/EP2007/005844 WO 20070702
- International Announcement: WO2008/006481 WO 20080117
- Main IPC: C07D217/00
- IPC: C07D217/00 ; A61K31/472
Abstract:
The invention provides compounds of formula (I), wherein Y, R, n and X are as defined in the description, a process for their preparation and pharmaceutical compositions containing them. The compounds of formula (I) inhibit the Transient Receptor Potential Vanilloid 1 (TRPV1), which plays a pivotal role in the development of post-inflammatory analgesia, therefore they can be used as analgesic and anti-inflammatory drugs.
Public/Granted literature
- US20100035923A1 VR1 VANILLOID RECEPTOR ANTAGONISTS WITH A IONONIC SUBSTRUCTURE Public/Granted day:2010-02-11
Information query
