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US07919633B2 Process for preparation of celecoxib 失效
塞来昔布的制备方法

Process for preparation of celecoxib
Abstract:
There is provided a process for preparation of celecoxib by reacting 4,4,4-trifluoro-1-[4-(methyl)phenyl]butane-1,3-dione with 4-sulphonamidophenylhydrazine or its salt in a solvent medium that contains an alkyl ester. There is also provided a process for the purification of celecoxib using aromatic hydrocarbon solvents.
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