Invention Grant
- Patent Title: Transgenic pig with altered incretin function
- Patent Title (中): 转基因猪具有改变的肠降血糖素功能
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Application No.: US12348294Application Date: 2009-01-04
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Publication No.: US07919673B2Publication Date: 2011-04-05
- Inventor: Eckhard Wolf , Simone Renner , Barbara Kessler , Rüdiger Wanke , Nadja Herbach , Alexander Pfeifer , Andreas Hofmann
- Applicant: Eckhard Wolf , Simone Renner , Barbara Kessler , Rüdiger Wanke , Nadja Herbach , Alexander Pfeifer , Andreas Hofmann
- Applicant Address: DE Munich DE Tiefenbach
- Assignee: Ludwig-Maximilians-Universitat,MWM Biomodels GmbH
- Current Assignee: Ludwig-Maximilians-Universitat,MWM Biomodels GmbH
- Current Assignee Address: DE Munich DE Tiefenbach
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: EP08000111 20080104
- Main IPC: A01K67/027
- IPC: A01K67/027 ; A01K67/00 ; A01K67/033
Abstract:
The present invention relates to transgenic pigs containing a dominant-negative incretin hormone receptor, namely the dominant-negative human glucose-dependent insulinotropic polypeptide receptor. The present invention furthermore relates to uses of these transgenic pigs as clinically relevant animal model systems for studying the pathogenesis and novel therapies for diabetes mellitus type 2, particularly for the maintenance and expansion of pancreatic β-cell mass.
Public/Granted literature
- US20090228993A1 Transgenic Pig With Altered Incretin Function Public/Granted day:2009-09-10
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