A circuit architecture for effective compensating the time skew of circuit is disclosed. The circuit architecture comprises a required compensation circuit, two duplicated circuits, and a time skew detection and compensation circuit, wherein these duplicated circuits are the duplicates of the required compensation circuit. A differential of logic 0 and logic 1 signals are simultaneously inputted into two duplicated circuits to output a first detection signal and a second detection signal, then the time skew detection and compensation circuit detects the time skew between a first detection signal and a second detection signal so as to generate a compensation signal to the required compensation circuit. Accordingly, the time skew existed in the required compensation circuit can be reduced or eliminated.