An image sensing apparatus has first and second image sensors is provided. In the image sensing apparatus, an optical system forms an optical image on the first and second image sensors; an area-of-interest extracting unit extracts an area of interest from image data output by the second image sensor; an area-of-interest information storage unit stores area-of-interest information indicative of a pixel area in the first image sensor corresponding to the position of the area of interest; a first storage unit stores image data from an entire pixel area of the first image sensor at a time interval; a second storage unit stores image data from the pixel area of the first image sensor indicated by the area-of-interest information, at a shorter time interval; and a combining unit combines the image data stored in the first and second storage units to generate combined image data.