Provided are a human interface device and a wireless communication method thereof. The wireless communication method of the human interface includes the steps of: setting up an occupancy channel of the host digital terminal and the wireless input unit by communicating data for setting up the occupancy channel through the emergency channel; transmitting, at the wireless input unit, operation data through the occupancy channel, and receiving, at the host digital terminal, the operation data; and when the operation data is not generated until a predetermined time lapses, enabling the wireless input unit and the host digital terminal to operate in an operation standby state, and confirming whether there is interference on the occupancy channel. Accordingly, efficiency of a frequency band is increased, and cost and size of the product can be reduced. Further, when interference on the occupancy channel is detected, a new occupancy channel can be set up so that reliability and efficiency of the wireless communication can be increased.