A system and method of accessing memory within an information handling system are disclosed. In one form, a method of accessing memory can include detecting a first operating value of a first memory access node accessible to a first processor, and initiating operation of the first memory access node to a first data rate value. The method can also include initiating operation of a second memory access node to a second data rate value. In one form, the second data rate value can be different from the first data rate value. The method can also include enabling a first application access to either the first memory access node or the second memory access node via an operating system enabled by the processor.