Invention Grant
US07923008B2 Methods for decreasing osteoclast formation or bone resorption using an antibody to osteoprotegerin binding protein
有权
使用抗骨质保护蛋白结合蛋白的方法减少破骨细胞形成或骨吸收
- Patent Title: Methods for decreasing osteoclast formation or bone resorption using an antibody to osteoprotegerin binding protein
- Patent Title (中): 使用抗骨质保护蛋白结合蛋白的方法减少破骨细胞形成或骨吸收
-
Application No.: US11336067Application Date: 2006-01-19
-
Publication No.: US07923008B2Publication Date: 2011-04-12
- Inventor: William J. Boyle
- Applicant: William J. Boyle
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Robert B. Winter
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/395 ; A61K38/16 ; A61K38/17 ; A61K38/18 ; A61K38/22 ; A61K38/29
Abstract:
A novel polypeptide, osteoprotegerin binding protein, involved in osteolcast maturation has been identified based upon its affinity for osteoprotegerin. Nucleic acid sequences encoding the polypeptide, or a fragment, analog or derivative thereof, vectors and host cells for production, methods of preparing osteoprotegerin binding protein, and binding assays are also described. Compositions and methods for the treatment of bone diseases such as osteoporosis, bone loss due to arthritis or metastasis, hypercalcemia, and Paget's disease are also provided.
Public/Granted literature
- US20060246064A1 Osteoprotegerin binding proteins Public/Granted day:2006-11-02
Information query
