Invention Grant
- Patent Title: Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens
- Patent Title (中): 树突细胞前体的体外增殖方法及其产生免疫原的用途
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Application No.: US12218899Application Date: 2008-07-17
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Publication No.: US07923247B2Publication Date: 2011-04-12
- Inventor: Ralph M. Steinman , Kayo Inaba , Gerold Schuler
- Applicant: Ralph M. Steinman , Kayo Inaba , Gerold Schuler
- Applicant Address: US NC Durham US NY New York
- Assignee: Argos Therapeutics, Inc.,The Rockefeller University
- Current Assignee: Argos Therapeutics, Inc.,The Rockefeller University
- Current Assignee Address: US NC Durham US NY New York
- Agent Elaine T. Sale; Leigh W. Thorne
- Main IPC: C12N5/02
- IPC: C12N5/02
Abstract:
A method for producing proliferating cultures of dendritic cell precursors is provided. Also provided is a method for producing mature dendritic cells in culture from the proliferating dendritic cell precursors. The cultures of mature dendritic cells provide an effective means of producing novel T cell dependent antigens comprised of dendritic cell modified antigens or dendritic cells pulsed with antigen, including particulates, which antigen is processed and expressed on the antigen-activated dendritic cell. The novel antigens of the invention may be used as immunogens for vaccines or for the treatment of disease. These antigens may also be used to treat autoimmune diseases such as juvenile diabetes and multiple sclerosis.
Public/Granted literature
- US20090029469A1 Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens Public/Granted day:2009-01-29
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