Invention Grant
- Patent Title: Modulators for amyloid beta
- Patent Title (中): 淀粉样β的调节剂
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Application No.: US12348370Application Date: 2009-01-05
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Publication No.: US07923450B2Publication Date: 2011-04-12
- Inventor: Karlheinz Baumann , Alexander Flohr , Erwin Goetschi , Helmut Jacobsen , Synese Jolidon , Thomas Luebbers
- Applicant: Karlheinz Baumann , Alexander Flohr , Erwin Goetschi , Helmut Jacobsen , Synese Jolidon , Thomas Luebbers
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- Priority: EP08150173 20080111
- Main IPC: A61K31/517
- IPC: A61K31/517 ; A61K31/519 ; A61K31/4365 ; A61K31/426 ; C07D471/04 ; C07D401/10 ; C07D277/82
Abstract:
The invention relates to compounds of formula wherein R1, R2, R3, R4, X and Y are as defined herein and to pharmaceutically active acid addition salts thereof. The compounds can be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.
Public/Granted literature
- US20090181965A1 MODULATORS FOR AMYLOID BETA Public/Granted day:2009-07-16
Information query
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