Invention Grant
US07923535B2 Tryptophan as a functional replacement for ADP-ribose-arginine in recombinant proteins
有权
色氨酸作为重组蛋白中ADP-核糖 - 精氨酸的功能替代物
- Patent Title: Tryptophan as a functional replacement for ADP-ribose-arginine in recombinant proteins
- Patent Title (中): 色氨酸作为重组蛋白中ADP-核糖 - 精氨酸的功能替代物
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Application No.: US12430023Application Date: 2009-04-24
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Publication No.: US07923535B2Publication Date: 2011-04-12
- Inventor: Joel Moss , Linda Stevens , Christelle Bourgeois , Rita Bortell
- Applicant: Joel Moss , Linda Stevens , Christelle Bourgeois , Rita Bortell
- Applicant Address: US DC Washington US MA Boston
- Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services,University of Massachusetts
- Current Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services,University of Massachusetts
- Current Assignee Address: US DC Washington US MA Boston
- Agency: Klarquist Sparkman, LLP.
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/38 ; C07K14/00
Abstract:
A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine residue is capable of being ADP-ribosylated. In another embodiment, methods are disclosed for modifying an immune response in a subject.
Public/Granted literature
- US20090203878A1 TRYPTOPHAN AS A FUNCTIONAL REPLACEMENT FOR ADP-RIBOSE-ARGININE IN RECOMBINANT PROTEINS Public/Granted day:2009-08-13
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