The invention provides a method of transferring single ended signal with interference-resistance. The transmission of the single ended signal includes an input device and an output device. The output device has its signal output terminal connected with a signal input terminal of the input device. A signal floating isolation circuit is connected with the signal output terminal of the output device and/or signal input terminal of the input device. The output signal or input signal is output or input via this floating isolation circuit. The isolation reference terminal of the output signal is coupled to ground of the output device through the isolation impedance, and/or the isolation reference terminal of the input signal is coupled to the ground of the input device. The signal output reference terminal of the output device and the signal input reference terminal of the input device are connected with each other. The invention also provides an input device and an output device both of which are used to transfer single ended signal with interference-resistance. By improving interface circuit design between the signals receiving side and transmitting side, interference signal entered into the signal channels are reduced, and the cost of implementation of the invention are also low.