Invention Grant
US07927603B2 Recombinant fusion-enzyme with repair activity on DNA lesions produced by UV radiation; its usage, preparation and purification method; a method to stabilize enzymes and treatment methods
有权
具有修复活性的重组融合酶通过紫外线辐射产生的DNA损伤; 其用途，制备和纯化方法; 稳定酶的方法和治疗方法
- Patent Title: Recombinant fusion-enzyme with repair activity on DNA lesions produced by UV radiation; its usage, preparation and purification method; a method to stabilize enzymes and treatment methods
- Patent Title (中): 具有修复活性的重组融合酶通过紫外线辐射产生的DNA损伤; 其用途，制备和纯化方法; 稳定酶的方法和治疗方法
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Application No.: US11750096Application Date: 2007-05-17
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Publication No.: US07927603B2Publication Date: 2011-04-19
- Inventor: Nestor Alberto Kerner , Guillermo Basílico , Mauricio Seigelchifer
- Applicant: Nestor Alberto Kerner , Guillermo Basílico , Mauricio Seigelchifer
- Agency: Lackenbach Siegel, LLP
- Priority: ARP060102256 20060531
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K38/43
Abstract:
A recombinant fusion enzyme repairs DNA damaged by UV radiation, and the method of preparing recombinant fusion enzyme. The method includes the fusion of an enzyme coded by a gene isolated from Micrococcus luteus and a stabilizing peptide having the amino acid sequence described in SEQ ID NO 2. A treatment method intended to repair DNA lesions produced in cells exposed to UV radiation and to repair cell anomalies or lesions produced by sun exposure. Such treatment consists of the administration of a effective amount of recombinant fusion enzyme, or a vector containing the gene coding to the recombinant fusion enzyme, to patients requiring such treatment.
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