Invention Grant
US07927790B2 Suppression of HIV-1 replication via inhibition of human flap endonuclease-1-mediated HIV-1 central DNA flap processing
有权
通过抑制人皮瓣内切核酸酶-1介导的HIV-1中心DNA瓣处理来抑制HIV-1复制
- Patent Title: Suppression of HIV-1 replication via inhibition of human flap endonuclease-1-mediated HIV-1 central DNA flap processing
- Patent Title (中): 通过抑制人皮瓣内切核酸酶-1介导的HIV-1中心DNA瓣处理来抑制HIV-1复制
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Application No.: US11440581Application Date: 2006-05-24
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Publication No.: US07927790B2Publication Date: 2011-04-19
- Inventor: Binghui Shen , Li Zheng
- Applicant: Binghui Shen , Li Zheng
- Applicant Address: US CA Duarte
- Assignee: City of Hope
- Current Assignee: City of Hope
- Current Assignee Address: US CA Duarte
- Agency: Perkins Coie LLP
- Agent Lauren Sliger
- Main IPC: C12Q1/70
- IPC: C12Q1/70 ; C12Q1/68
Abstract:
FEN-1 is involved in processing HIV central DNA flap (CDF) and is a target for intervention of HIV-1 replication. Inhibition of HIV-1 CDF removal by expression of D181A FEN-1 mutant suppresses viral DNA replication, further demonstrating that FEN-1 is a target. Methods of identifying and using molecules that inhibit FEN-1 processing HIV-1 CDF and other methods of inhibiting FEN-1 processing are provided. Useful small molecules specifically suppress FEN-1 cleavage of HIV CDF but have little effect on FEN-1's function in RNA-DNA primer removal. Pentamidine inhibits HIV replication by suppressing FEN-1-mediated HIV-CDF processing.
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