Invention Grant
- Patent Title: Methods for identifying modulators of apoptosis
- Patent Title (中): 识别凋亡调节剂的方法
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Application No.: US12206670Application Date: 2008-09-08
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Publication No.: US07927816B2Publication Date: 2011-04-19
- Inventor: John C. Reed , Bin Guo
- Applicant: John C. Reed , Bin Guo
- Applicant Address: US CA San Diego
- Assignee: Sanford-Burnham Medical Research Institute
- Current Assignee: Sanford-Burnham Medical Research Institute
- Current Assignee Address: US CA San Diego
- Agent Jones Day
- Main IPC: G01N33/53
- IPC: G01N33/53 ; A61K38/00 ; C07K14/00
Abstract:
The invention provides a method of identifying an effective compound that modulates the binding of Humanin to Bax or Bid. The invention also provides a method of identifying an effective compound that modulates an activity of Bax or Bid. In addition, the invention provides a method of identifying a Humanin-like compound that binds to Bax or Bid or modulates an activity of Bax or Bid, or inhibits the apoptotic activity of Bax or Bid. The invention further provides an isolated polypeptide containing a mitochondrial-derived form of Humanin (SEQ ID NO:3) or a functional fragment thereof where the fragment contains the methionine at position 16 of SEQ ID NO:3.
Public/Granted literature
- US20090075292A1 METHODS FOR IDENTIFYING MODULATORS OF APOPTOSIS Public/Granted day:2009-03-19
Information query
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