Invention Grant
- Patent Title: Detection and amplification of ligands
- Patent Title (中): 配体的检测和扩增
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Application No.: US11751065Application Date: 2007-05-21
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Publication No.: US07927827B2Publication Date: 2011-04-19
- Inventor: Gary D. Niehaus , Christopher J. Woolverton , Kathleen J. Doane , Steven P. Schmidt , Steven A. Signs
- Applicant: Gary D. Niehaus , Christopher J. Woolverton , Kathleen J. Doane , Steven P. Schmidt , Steven A. Signs
- Applicant Address: US OH Kent
- Assignee: Kent State University
- Current Assignee: Kent State University
- Current Assignee Address: US OH Kent
- Agency: Hahn Loeser + Parks LLP
- Agent Scott M. Oldham, Esq.
- Main IPC: G01N33/53
- IPC: G01N33/53 ; C12Q1/00
Abstract:
A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an enzyme, whereby the enzyme is separated from its substrate by an receptor; and a receptor engineered to inhibit the active of site of an enzyme only in the absence of a ligand. Also provided are methods for the automatic detection of ligands.
Public/Granted literature
- US20070218508A1 DETECTION AND AMPLIFICATION OF LIGANDS Public/Granted day:2007-09-20
Information query
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