Invention Grant
- Patent Title: Nuclease resistant double-stranded ribonucleic acid
- Patent Title (中): 耐核酸酶双链核糖核酸
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Application No.: US11139089Application Date: 2005-05-27
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Publication No.: US07928217B2Publication Date: 2011-04-19
- Inventor: Hans-Peter Vornlocher , Ingo Roehl , Philipp Hadwiger , Tracy Stage Zimmermann , Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc
- Applicant: Hans-Peter Vornlocher , Ingo Roehl , Philipp Hadwiger , Tracy Stage Zimmermann , Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: LeClairRyan
- Agent Jeffrey N. Townes
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C12N15/11
Abstract:
This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.
Public/Granted literature
- US20060094678A1 Nuclease resistant double-stranded ribonucleic acid Public/Granted day:2006-05-04
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