Invention Grant
US07928219B2 RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (SINA)
有权
RNA干扰介导使用短干扰核酸（SINA）抑制胎盘生长因子基因表达
- Patent Title: RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (SINA)
- Patent Title (中): RNA干扰介导使用短干扰核酸（SINA）抑制胎盘生长因子基因表达
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Application No.: US12171111Application Date: 2008-07-10
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Publication No.: US07928219B2Publication Date: 2011-04-19
- Inventor: James McSwiggen , Leonid Beigelman
- Applicant: James McSwiggen , Leonid Beigelman
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Laura M. Ginkel; David A. Muthard
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04
Abstract:
This invention relates to compounds, compositions, and methods useful for modulating placental growth factor (e.g., PGF-1 or PlGF-1, PGF-2 or PlGF-2, and/or PGF-3 or PlGF-3) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of placental growth factor gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of placental growth factor genes.
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