Methods of determining an acquisition time adapted to a region of interest for a nuclear imaging process of a patient include detecting radiation from at least a first viewing angle during a first test amount of time, generating first test data from the detected radiation, reconstructing a nuclear event distribution from the first test data, determining a test signal-to-noise ratio for the reconstructed nuclear event distribution within the region of interest, and determining the acquisition time using the test signal-to-noise ratio and the first test amount of time.