A tissue closure device has an elongate body with a first portion and a second portion. A wound closure member is also provided. In operation, a wound closure member is releasably held on a distal end of the first portion. The wound closure member is advanced within the patient until it is placed on top of and over a wound in tissue. Flowable adhesive is injected through a lume of the second portion onto the wound closure member and tissue surrounding the wound closure member. The wound closure member applicator holds the wound closure member in place, allowing the adhesive to at least partially set. The applicator is then removed from the wound closure member. Thus, an adhesive wound closure member is attached to close an opening in tissue.