Invention Grant
US07931907B2 Hepatitis B virus DNA polymerase and surface antigen variants and methods of using same
有权
乙型肝炎病毒DNA聚合酶和表面抗原变体及使用方法
- Patent Title: Hepatitis B virus DNA polymerase and surface antigen variants and methods of using same
- Patent Title (中): 乙型肝炎病毒DNA聚合酶和表面抗原变体及使用方法
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Application No.: US12245994Application Date: 2008-10-06
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Publication No.: US07931907B2Publication Date: 2011-04-26
- Inventor: Angeline Ingrid Bartholomeusz , Stephen Alister Locarnini , Anna Ayres , Margaret Rose Littlejohn , Geoffrey William McCaughan , Peter William Angus
- Applicant: Angeline Ingrid Bartholomeusz , Stephen Alister Locarnini , Anna Ayres , Margaret Rose Littlejohn , Geoffrey William McCaughan , Peter William Angus
- Applicant Address: AU Parkville, Victoria AU Heidelberg, Victoria AU Camperdown
- Assignee: Melbourne Health,Austin and Repatriation Medical Centre,Central Sydney Area Health Service
- Current Assignee: Melbourne Health,Austin and Repatriation Medical Centre,Central Sydney Area Health Service
- Current Assignee Address: AU Parkville, Victoria AU Heidelberg, Victoria AU Camperdown
- Agency: Nixon & Vanderhye, P.C.
- Priority: AUPQ8109 20000609
- Main IPC: A61K39/29
- IPC: A61K39/29 ; A61K39/38 ; C12Q1/70

Abstract:
The present invention relates generally to viral variants exhibiting reduced sensitivity to agents and in particular nucleoside analogues. More particularly, the present invention is directed to hepatitis B virus variants exhibiting complete or partial resistance to nucleoside analogues. The variants may also comprise corresponding mutations affecting immunological interactivity to viral surface components. The present invention further contemplates assays for detecting such viral variants which assays are useful in monitoring anti-viral therapeutic regimes and in developing new or modified vaccines directed against viral agents and in particular hepatitis B virus variants. The present invention also contemplates the use of the viral variants to screen for agents capable of inhibiting infection, replication and/or release of the virus.
Public/Granted literature
- US20090155771A1 HEPATITIS B VIRUS DNA POLYMERASE AND SURFACE ANTIGEN VARIANTS AND METHODS OF USING SAME Public/Granted day:2009-06-18
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