Invention Grant
US07932061B2 Method enabling the use of extracellular ribonucleic acid (RNA) extracted from plasma of serum to detect, monitor or evaluate cancer or premalignant conditions
有权
能够使用从血清中提取的细胞外核糖核酸（RNA）来检测，监测或评估癌症或癌前病症
- Patent Title: Method enabling the use of extracellular ribonucleic acid (RNA) extracted from plasma of serum to detect, monitor or evaluate cancer or premalignant conditions
- Patent Title (中): 能够使用从血清中提取的细胞外核糖核酸（RNA）来检测，监测或评估癌症或癌前病症
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Application No.: US11364842Application Date: 2006-02-28
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Publication No.: US07932061B2Publication Date: 2011-04-26
- Inventor: Michael Kopreski
- Applicant: Michael Kopreski
- Applicant Address: US NJ Long Valley
- Assignee: OncoMEDx, Inc.
- Current Assignee: OncoMEDx, Inc.
- Current Assignee Address: US NJ Long Valley
- Agency: McDonnell Boehnen Hulbert & Berghoff
- Main IPC: C12P19/34
- IPC: C12P19/34 ; C12Q1/68 ; C07H21/02 ; C07H21/04 ; C07H21/00
Abstract:
This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Specifically, this invention enables the extraction of circulating RNA from plasma or serum and utilizes nucleic acid amplification assays for the identification, detection, inference, monitoring, or evaluation of any neoplasm, benign, premalignant, or malignant, in humans or other animals, which might be associated with that RNA. Further, this invention allows the qualitative or quantitative detection of tumor-derived or associated extracellular RNA circulating in the plasma or serum of humans or animals with or without any prior knowledge of the presence of cancer or premalignant tissue.
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