Invention Grant
- Patent Title: DNA participating in hydroxylation of macrolide compound
- Patent Title (中): 参与大环内酯化合物羟基化的DNA
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Application No.: US10577655Application Date: 2004-11-25
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Publication No.: US07932083B2Publication Date: 2011-04-26
- Inventor: Kazuhiro Machida , Takashi Nakashima , Yasuhide Aritoku , Toshio Tsuchida
- Applicant: Kazuhiro Machida , Takashi Nakashima , Yasuhide Aritoku , Toshio Tsuchida
- Applicant Address: JP Tokyo JP Tokyo
- Assignee: Mercian Corporation,Eisai R&D Management Co., Ltd.
- Current Assignee: Mercian Corporation,Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2003-396828 20031127
- International Application: PCT/JP2004/017906 WO 20041125
- International Announcement: WO2005/052152 WO 20050609
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N15/00 ; C12P21/06 ; C07H21/02 ; C07H21/04
Abstract:
The present invention provides a DNA participating in biological transformation of a macrolide compound 11107B. The present invention provides, particularly, a DNA participating in biological transformation of a macrolide compound 11107B represented by the formula (I) into a 16-position hydroxy macrolide compound 11107D represented by the formula (II), the DNA encoding a protein having 16-position hydroxylating enzymatic activity or ferredoxin, to a method of isolating the DNA, to a protein encoded by the DNA, a plasmid carrying the DNA, a transformant obtained by transforming using the plasmid and a method of producing a 16-position hydroxy compound by using the transformant.
Public/Granted literature
- US20080070286A1 Dna Participating in Hydroxylation of Macrolide Compound Public/Granted day:2008-03-20
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