Invention Grant
US07932226B2 NFκB transcriptional activity inhibitory agent and anti-inflammatory agent and a steroid action enhancing agent
有权
NF＆kgr; B转录活性抑制剂和抗炎剂和类固醇作用增强剂
- Patent Title: NFκB transcriptional activity inhibitory agent and anti-inflammatory agent and a steroid action enhancing agent
- Patent Title (中): NF＆kgr; B转录活性抑制剂和抗炎剂和类固醇作用增强剂
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Application No.: US11631202Application Date: 2005-06-28
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Publication No.: US07932226B2Publication Date: 2011-04-26
- Inventor: Kazuki Okamoto , Fumihide Isohashi
- Applicant: Kazuki Okamoto , Fumihide Isohashi
- Applicant Address: JP Kawasaki-shi
- Assignee: St. Marianna University School of Medicine
- Current Assignee: St. Marianna University School of Medicine
- Current Assignee Address: JP Kawasaki-shi
- Agency: Marshall, Gerstein & Borun LLP
- Priority: JP2004-192160 20040629
- International Application: PCT/JP2005/011851 WO 20050628
- International Announcement: WO2006/001453 WO 20060105
- Main IPC: A61K38/16
- IPC: A61K38/16 ; C07K14/00
Abstract:
It is intended to surely and effectively inhibit the transcriptional activity of NFκB and to obtain a more effective anti-inflammatory effect. Further, it is intended to obtain an equivalent effect even if the amount used of a steroid agent is reduced.An agent is characterized by containing MTI-II, especially a nucleic acid sequence of SEQ ID NO: 1, or a peptide of SEQ ID NO: 2. This MTI-II peptide is preferably a peptide containing at least an acidic amino acid domain (SEQ ID NO: 3). Further, a steroid agent such as triamcinolone acetonide is used concomitantly with MTI-II, especially the nucleic acid sequence of SEQ ID NO: 1 or the peptide of SEQ ID NO: 2.
Public/Granted literature
Information query
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