Invention Grant
US07932257B2 Substituted pyrazolo[4,3-d]pyrimidines as aurora kinase inhibitors
失效
取代的吡唑并[4,3-d]嘧啶作为极光激酶抑制剂
![Substituted pyrazolo[4,3-d]pyrimidines as aurora kinase inhibitors](/docs/US/2011-04-26/US07932257B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted pyrazolo[4,3-d]pyrimidines as aurora kinase inhibitors
- Patent Title (中): 取代的吡唑并[4,3-d]嘧啶作为极光激酶抑制剂
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Application No.: US11490983Application Date: 2006-07-21
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Publication No.: US07932257B2Publication Date: 2011-04-26
- Inventor: Johan D. Oslob , Chul Hyun Yu
- Applicant: Johan D. Oslob , Chul Hyun Yu
- Applicant Address: US CA South San Francisco
- Assignee: Sunesis Pharmaceuticals, Inc.
- Current Assignee: Sunesis Pharmaceuticals, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Choate, Hall & Stewart LLP
- Agent Andrea L. C. Robidoux; Emilie Porter Huck
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; A61P35/00 ; A61P25/28 ; A61P29/00 ; C07D487/06
![Substituted pyrazolo[4,3-d]pyrimidines as aurora kinase inhibitors](/abs-image/US/2011/04/26/US07932257B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides compounds having the formula: wherein A-B together represent one of the following structures: wherein one of is a double bond, as valency permits; and R2, R4, X1A, X2A, X1B, X2B, L1, L2, Y and Z are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., Aurora), and thus are useful, for example, for the treatment of Aurora mediated diseases.
Public/Granted literature
- US20070027166A1 Pyrazolo pyrimidines useful as aurora kinase inhibitors Public/Granted day:2007-02-01
Information query
