Invention Grant
US07932258B2 Use of a partially neutralized, anionic (meth) acrylate copolymer as a coating for the production of a medicament pharmaceutical form releasing active substance at reduced pH values 有权
使用部分中和的阴离子(甲基)丙烯酸酯共聚物作为涂层,用于制备在降低的pH值下释放活性物质的药物形式

  • Patent Title: Use of a partially neutralized, anionic (meth) acrylate copolymer as a coating for the production of a medicament pharmaceutical form releasing active substance at reduced pH values
  • Patent Title (中): 使用部分中和的阴离子(甲基)丙烯酸酯共聚物作为涂层,用于制备在降低的pH值下释放活性物质的药物形式
  • Application No.: US11994440
    Application Date: 2006-04-05
  • Publication No.: US07932258B2
    Publication Date: 2011-04-26
  • Inventor: Hans-Ulrich PetereitManfred Assmus
  • Applicant: Hans-Ulrich PetereitManfred Assmus
  • Applicant Address: DE Darmstadt
  • Assignee: Evonik Roehm GmbH
  • Current Assignee: Evonik Roehm GmbH
  • Current Assignee Address: DE Darmstadt
  • Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
  • Priority: DE102005032806 20050712
  • International Application: PCT/EP2006/003115 WO 20060405
  • International Announcement: WO2007/006353 WO 20070118
  • Main IPC: A61K31/522
  • IPC: A61K31/522
Use of a partially neutralized, anionic (meth) acrylate copolymer as a coating for the production of a medicament pharmaceutical form releasing active substance at reduced pH values
Abstract:
The invention relates to the use of a partially neutralized, anionic (meth)acrylate copolymer comprising radically polymerized units of 25 to 95 percent by weight of C1 to C4 alkyl esters of acrylic or methacrylic acid and 5 to 75 percent by weight of (meth)acrylate monomers with an anionic group, at least 4 percent of which are neutralized by means of a base, for producing a medicament that is provided with an active substance-containing core and is coated with the partially neutralized, anionic (meth)acrylate copolymer. The medicament releases at least 30 percent of the active substance contained therein in 30 minutes at a pH at which the active substance is sufficiently soluble and stable and at which the corresponding medicament that is coated with the non-neutralized anionic (meth)acrylate polymer releases less than 10 percent of the active substance contained therein.
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