Invention Grant
US07932260B2 Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
有权
喹唑啉酮作为人磷脂酰肌醇3-激酶三角体的抑制剂
- Patent Title: Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
- Patent Title (中): 喹唑啉酮作为人磷脂酰肌醇3-激酶三角体的抑制剂
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Application No.: US11596092Application Date: 2005-05-12
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Publication No.: US07932260B2Publication Date: 2011-04-26
- Inventor: Kerry W. Fowler , Danwen Huang , Edward A. Kesicki , Hua Chee Ooi , Amy Oliver , Fuqiang Ruan , Jennifer Treiberg
- Applicant: Kerry W. Fowler , Danwen Huang , Edward A. Kesicki , Hua Chee Ooi , Amy Oliver , Fuqiang Ruan , Jennifer Treiberg
- Applicant Address: US WA Bothell
- Assignee: ICOS Corporation
- Current Assignee: ICOS Corporation
- Current Assignee Address: US WA Bothell
- Agency: Morrison & Foerster LLP
- International Application: PCT/US2005/016778 WO 20050512
- International Announcement: WO2005/113556 WO 20051201
- Main IPC: A61K31/517
- IPC: A61K31/517
Abstract:
The invention provides a class of substituted quinazolinone compounds and methods of treating diseases mediated by PI3Kδ activity. The disclosed compounds are useful in treating diseases such as bone-resorption disorders; and cancer, especially hematopoietic cancers, lymphomas, multiple myelomas and leukemia. The compounds are also useful in disrupting or inhibiting cellular processes such as leukocyte function or accumulation, neutrophils function, lymphocyte proliferation, and endogenous immune responses.
Public/Granted literature
- US20080275067A1 Quinazolinones as Inhibitors of Human Phosphatidylinositol 3-Kinase Delta Public/Granted day:2008-11-06
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