Invention Grant
US07932261B2 Macrocycle derivatives useful as inhibitors of β-secretase (BACE)
有权
可用作分泌抑制剂（BACE）的大分子衍生物
- Patent Title: Macrocycle derivatives useful as inhibitors of β-secretase (BACE)
- Patent Title (中): 可用作分泌抑制剂（BACE）的大分子衍生物
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Application No.: US11671732Application Date: 2007-02-06
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Publication No.: US07932261B2Publication Date: 2011-04-26
- Inventor: Ellen W. Baxter , François P. Bischoff , Hans De Winter , Chih Yung Ho , Yifang Huang , Michael H. Parker , Allen B. Reitz , Charles H. Reynolds , Eric D. Strobel
- Applicant: Ellen W. Baxter , François P. Bischoff , Hans De Winter , Chih Yung Ho , Yifang Huang , Michael H. Parker , Allen B. Reitz , Charles H. Reynolds , Eric D. Strobel
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/517
Abstract:
The present invention is directed to macrocycle derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.
Public/Granted literature
- US20070232630A1 MACROCYCLE DERIVATIVES USEFUL AS INHIBITORS OF beta-SECRETASE (BACE) Public/Granted day:2007-10-04
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