Invention Grant
- Patent Title: Recombinant production of mixtures of antibodies
-
Application No.: US11593280Application Date: 2006-11-06
-
Publication No.: US07932360B2Publication Date: 2011-04-26
- Inventor: Patrick H. C. Van Berkel , Ronald Hendrik Peter Brus , Ton Logtenberg , Abraham Bout
- Applicant: Patrick H. C. Van Berkel , Ronald Hendrik Peter Brus , Ton Logtenberg , Abraham Bout
- Applicant Address: NL Utrecht
- Assignee: Merus B.V.
- Current Assignee: Merus B.V.
- Current Assignee Address: NL Utrecht
- Agency: TraskBritt
- Priority: EP02077953 20020718; WOPCT/EP03/50201 20030527
- Main IPC: C12P21/08
- IPC: C12P21/08 ; A61K39/395

Abstract:
The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
Public/Granted literature
- US20070054362A1 Recombinant production of mixtures of antibodies Public/Granted day:2007-03-08
Information query