Invention Grant
US07932364B2 Compositions and methods for the preparation of human growth hormone glycosylation mutants
有权
用于制备人生长激素糖基化突变体的组合物和方法
- Patent Title: Compositions and methods for the preparation of human growth hormone glycosylation mutants
- Patent Title (中): 用于制备人生长激素糖基化突变体的组合物和方法
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Application No.: US10556094Application Date: 2004-05-07
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Publication No.: US07932364B2Publication Date: 2011-04-26
- Inventor: Shawn DeFrees , Henrik Clausen
- Applicant: Shawn DeFrees , Henrik Clausen
- Applicant Address: DE Bagsvaerd
- Assignee: Novo Nordisk A/S
- Current Assignee: Novo Nordisk A/S
- Current Assignee Address: DE Bagsvaerd
- Agency: Leydig, Voit & Mayer, Ltd.
- International Application: PCT/US2004/014254 WO 20040507
- International Announcement: WO2004/103275 WO 20041202
- Main IPC: C07K1/00
- IPC: C07K1/00 ; C07K14/00
Abstract:
The present invention relates to mutants of human growth hormone, which contain newly introduced N-linked or O-linked glycosylation site(s), such that these recombinantly produced polypeptides have glycosylation patterns distinctly different from that of the naturally occurring human growth hormone. The polynucleotide coding sequences for the mutants, expression cassettes comprising the coding sequences, cells expressing the mutants, and methods for producing the mutants are also disclosed. Further disclosed are pharmaceutical compositions comprising the mutants and method for using the mutants.
Public/Granted literature
- US20080102083A1 Compositions and Methods for the Preparation of Human Growth Hormone Glycosylation Mutants Public/Granted day:2008-05-01
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