A CT system includes a scintillator array having a first length in an axial direction of the CT system, the scintillator array includes a plurality of scintillator cells along the first length. The CT system includes a controller configured to repeatedly position a subject fore and aft along the axial direction and over a second length of the CT system, the second length greater than the first length, energize an x-ray source to emit x-rays toward the subject while the subject is being repeatedly positioned, and obtain non-uniform projection data of the subject from the scintillator array, the non-uniform projection data comprising the x-rays received from the x-ray source while the subject is repeatedly positioned. The CT system includes a computer programmed to reconstruct a plurality of temporally non-uniformly spaced images from the non-uniform projection data, interpolate the plurality of non-uniform images to form a plurality of temporally uniform images, and apply a perfusion map generation process to the plurality of temporally uniform images.