A bioinformatics method, software, database and system for compiling attribute combinations that co-associate with a query attribute (i.e., an attribute of interest) are presented in which expanded attribute profiles associated with a group of query-attribute-positive individuals and expanded attribute profiles associated with a group of query-attribute-negative individuals are accessed, and combinations of attributes having a higher frequency of occurrence in the set of expanded attribute profiles associated with the group of query-attribute-positive individuals are identified and stored to generate a compilation of attribute combinations that co-associate with the query attribute.