A method of determining whether a liquid amount and/or quality of a liquid reagent held in a reagent holding portion are/is normal or not in a microchip that includes the steps of measuring each liquid reagent held in the reagent holding portion with a first measuring portion, mixing, at least, two or more types of measured liquid reagents in a first mixing portion, and evaluating the liquid amount and/or quality of obtained liquid mixture and determining, based on the evaluation, whether or not the liquid amount and/or quality of the liquid reagents are/is normal, as well as a liquid-reagent-containing microchip are provided. A method of easily determining whether a liquid amount and/or quality of liquid reagents in a microchip are/is normal or not and a microchip in which the method can be performed are provided.