Invention Grant
- Patent Title: Antibodies to IL-6 and use thereof
- Patent Title (中): IL-6抗体及其用途
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Application No.: US12153612Application Date: 2008-05-21
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Publication No.: US07935340B2Publication Date: 2011-05-03
- Inventor: Leon Garcia-Martinez , Anne Elisabeth Carvalho Jensen , Katie Olson , Ben Dutzar , Ethan Ojala , Brian Kovacevich , John Latham , Jeffrey T. L. Smith
- Applicant: Leon Garcia-Martinez , Anne Elisabeth Carvalho Jensen , Katie Olson , Ben Dutzar , Ethan Ojala , Brian Kovacevich , John Latham , Jeffrey T. L. Smith
- Applicant Address: US NV Las Vegas
- Assignee: AlderBio Holdings LLC
- Current Assignee: AlderBio Holdings LLC
- Current Assignee Address: US NV Las Vegas
- Agency: Hunton & Williams LLP
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/24 ; C12P21/08

Abstract:
The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.
Public/Granted literature
- US20090028784A1 Antibodies to IL-6 and use thereof Public/Granted day:2009-01-29
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